Possible Interaction: Steroids and Vitamin B 6

“… vitamin B6 nutritional status of … respond to steroid hormones — impose an additional level of cell‐specific control over steroid hormone regulation of gene expression and will serve as the … review.—Tully, D. B., Allgood, V. E., Cidlowski, J. A. Modulation of steroid receptor‐mediated gene expression by vitamin B6.”

“It is likely that the use of prophylactic pyridoxine and steroids reduced the duration and intensity of symptoms in the second cycle.”

“However, drugs such as methotrexate … use or accelerated catabolism of vitamin B6 has been shown in chronic inflammatory diseases, particularly RA.2,6–8 Recently, it has been shown that … betaine-homocysteine methyltransferase, which transforms homocysteine in methionine with consumption of betaine as methyl donor coenzyme.10 Moreover, steroids …”

“These results suggest that vitamin B6 modulates steroid hormone-mediated gene expression through its influence on a functional or cooperative interaction between steroid hormone receptors and the transcription factor NF1.”

“We have investigated the mechanism by which vitamin B6 acts to modulate steroid hormone-mediated gene expression.”

“ E steroids compete with pyridoxal phosphate-dependent apoenzymes for the cofactor in vitro, and a similar effect probably occurs in vivo.”

“Apparently the steroid hormones have the effect of loosening the binding of some pyridoxine to its enzyme.”

“Pyridoxal-5'-phosphate PALP ), the coenzyme form of vitamin B 6 interacts with receptors of steroid hormones in vitro, inhibiting their binding with DNA [6].”

“Acute repletion with vitamin B6 (0.5-1 h before killing) further increased the uptake of the steroid.”

“Pre-incubation of the hepatocytes with pyridoxal phosphate resulted in a further increase in the uptake of the steroid.”

“Evidence is presented that these actions of steroid and nonsteroid metabolites can cause a redistribution of pyridoxal phosphate between apoenzymes.”

“ Vitamin B6 has recently been found to modulate gene expression not only for steroid hormone-responsive or PLP-dependent enzymes but also for steroid- and PLP-unrelated proteins such as serum albumin.”