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“Excess dietary tyrosine significantly decreased the fecal excretion of neutral steroids , whereas total steroid excretion was not significantly changed.”
“These studies suggest that inactivation was due to the incorporation of a bulky group into the aromatic ring of a tyrosine present at the steroid binding site thus blocking its ability to participate in hydrophobic interactions with the ligand.”
Journal of steroid biochemistry • 1982 | View Paper
“The only tyrosine residue of the uteroglobin subunit changes its absorption spectrum as a consequence of steroid binding, and the binding reaction is accompanied by a positive entropy change.”