Possible Interaction: Steroids and Polypeptides

“Data presented here demonstrates the requirement for two types of regulator molecules in the control of fibrinogen gene expression; a polypeptide hormone (HSF) that increases transcription and a steroid (DEX) that enhances the action of the polypeptide.”

“The inhibitory actions of the steroids on the secretory responses to vasoactive intestinal polypeptide , forskolin, and 8-bromo-cAMP were specifically quenched by inclusion in the medium of the annexin 1 antisense ODN (50 nM) or a neutralizing antiannexin 1 monoclonal antibody (antiannexin 1 mAb, diluted 1:15,000).”

“Recent studies suggest that steroid effects on uterine cell proliferation may be moderated by polypeptide growth factors.”

“Evidently, the steroid and polypeptide mutually enhance binding to this pancreatic protein, and depending on their concentrations form structures of widely varying sizes.”

“The lesion site is rich in luteinising hormone releasing hormone5, and it seems likely that the discharge of this polypeptide triggers the rapid and sustained increase in the production of ovarian steroids , particularly of oestrogen, observed during this period4.”

“By binding to an aminoacyl-tRNA, a steroid can control polypeptide synthesis in a model in vitro system by inhibiting chain elongation under conditions where aminoacyl-tRNA concentration is rate-limiting.”