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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Steroids
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“Affinity and the number of binding sites were affected in the presence of cupric ions , indicating a mixed type inhibition of the binding of steroid to receptor.”
Effect of Cu2+ ions on the binding of estrogen to the human myometrial estrogen binding protein.“The strand scission/nicking of DNA by the test steroid was enhanced by some metal ions, especially the Cu(II).”
Steroid induced single strand breaks in DNA mediated by active oxygen species and its biological consequences.“The effects of copper ions on the binding of steroids to receptors revealed that the inhibitory effect of Cu++ was apparent at 10(-6)M, ANd the binding capacities decreased to 10% at 10(-2)M Cu++.”
“The kinetic study demonstrated that Cu++ was a competitive inhibitor of steroid hormone-receptor binding (Ki divided by 2.7 X 10(-5)M to estrogen receptor; Ki divided by 5.1 X 10(-6)M to progesterone receptor).”
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