Possible Interaction: Steroids and Calcium Supplement

“However, it is unknown whether sex steroids also directly regulate renal calcium and phosphate handling, hereby potentially indirectly impacting on bone.”

“Our results indicated that steroids may sufficiently control cytoplasmic calcium concentration within physiological and therapeutic range.”

“Bile acids and other steroids modify large conductance, calcium‐ and voltage‐gated potassium (BK) channel activity contributing to non‐genomic modulation of myogenic tone.”

“Rapid steroid-triggered signaling through calcium , amine release, and kinase activation also impacts the regulation of gene expression by steroids , sometimes requiring integration with nuclear steroid receptor function.”

“Both types of steroids probably are useful in therapy because they prevent the uptake and utilization calcium ions which are essential for contraction of vascular smooth muscle cells.”

“ Steroids may suppress growth by direct action on cell metabolism, by inhibition of growth hormone or somatomedin and/or by effects on calcium and phosphorus metabolism.”

“Other commonly used medications to further decrease calcium include bisphosphates, calcitonin, steroids , and (rarely) furosemide.”

“Our data show a statistically significant increase of [Ca2+]i in the acute condition and in long-term treated cultures, suggesting that androgen steroids modulate intracellular levels of calcium independent of incubation time or compound identity.”

“This suggests that the sex steroid hormones may modulate serum levels of ionized Mg and the ionized Ca/Mg ratio.”

“The pathogenesis is complex, there exists evidence that steroids cause a reduction of circulating testosterone and estrogen concentration and adversely affect calcium balance.”