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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Steroids
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Consistent with the decrease in ACTH , all steroids except testosterone reacted negatively to Dex, independently of the dose (0.5 and 1.5 mg administered twice daily for 4.5 days).”
“ ACTH regulates steroid biosynthesis in the adrenal cortex by exerting its effects via the ACTH receptor (melanocortin- 2 receptor, MC2R).”
“In normal circumstances their secretion is tightly regulated by a complex servo mechanism through which the steroids suppress the synthesis and release of ACTH and its hypothalamic releasing factors (CRH and AVP) and thereby reduce the positive drive to the adrenal cortex.”
“ ACTH is the major regulator of adrenal cortex function, having acute and chronic effects on steroid synthesis and secretion.”
“The precise molecular mechanisms by which ACTH stimulates steroid synthesis and secretion, as well as cell hypertrophy, survival, and migration are still poorly understood.”
“In addition, when the perfused rat adrenal was stimulated with ACTH , significant increases in steroid secretion and perfusion medium flow rate were accompanied by significantly increased secretion of immunoreactive endothelin into the adrenal vein.”
“In culture medium containing a higher concentration of BSA, Y-1 cells did not become spherical as is usually the case when steroid production is stimulated by ACTH or cyclic AMP.”
Composition of culture media for steroid hormone secretion by murine adrenal tumor cells, Y-1 clone.“ ACTH administration for 3 days resulted in an exaggerated increase in the excretion of these steroids , suggesting ACTH dependence of these steroids in patients with GSA.”
“LDL and ACTH also influenced the pattern of steroids secreted by each cell type.”
“ ACTH causes an increase in the synthesis of both the mitochondrial and the microsomal forms of cytochrome P-450 involved in steroid hormone biosynthesis, as well as of the iron-sulfur protein involved in transferring electrons to the mitochondrial forms of cytochrome P-450, namely, adrenodoxin.”
“Patients with CAHs are treated with steroids that suppress ACTH levels and prevent adrenal gland hyperplasia.”
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