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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
St John's Wort
drug:
Fostemsavir
Research Papers that Mention the Interaction
“Temsavir is primarily metabolized through hydrolysis but also … cytochrome P-450 (CYP) oxidation; therefore, coadministration of fostemsavir with strong CYP3A inducers such as …, carbamazepine, phenytoin, mitotane, enzalutamide, or St John's wort is contraindicated because it may result in significantly lower temsavir exposure, which can ultimately impair virologic response.”
Fostemsavir: The first oral attachment inhibitor for treatment of HIV-1 infection.
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