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Last Updated: 3 years ago

Possible Interaction: Spironolactone and Vitamin D

supplement:

Vitamin D

Research Papers that Mention the Interaction

Combined treatment of NM‐exposed mice with VD3 and SP synergistically inhibited the expression of iNOS in the skin and decreased the expression of matrix metallopeptidase‐9, C‐C motif chemokine ligand 2, interleukin (IL)‐1α, and IL‐1β.
Here, we show that combined treatment of vitamin D3 (VD3) and spironolactone (SP), a mineralocorticoid receptor antagonist, significantly improves the resolution of inflammation and accelerates wound healing after NM exposure.
SP enhanced the inhibitory effect of VD3 on nuclear factor‐kB activity.
Annals of the New York Academy of Sciences  •  2020  |  View Paper