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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Spironolactone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Spironolactone (400 mg/day) inhibited ACTH (80 U/day)-induced kaliuresis, but not the Na+ retention produced by ACTH or cortisol (240 mg/day) and only blunted the modest Na+ retention induced by cortisol (120 mg/day).”
Adrenocorticotropin and cortisol-induced changes in urinary sodium and potassium excretion in man: effects of spironolactone and RU486.“Incremental PA response to ACTH was less than control on day 10 of spironolactone , but other corticosteroid responses to ACTH were not different during control and days 5 or 10 of treatment.”
“Given separately, spironolactone and RU38486 blunted the pressor response to ACTH and the increased epithelial sodium channel activity; combined mineralocorticoid and glucocorticoid receptor blockade was required to resolve the response to ACTH excess.”
Mineralocorticoid and Glucocorticoid Receptors Stimulate Epithelial Sodium Channel Activity in a Mouse Model of Cushing Syndrome
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