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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Ascorbic acid , at 0.1 mM, induces a slow loss of the low affinity component of [3H]spiroperidol binding in these tissues.”
Guanyl nucleotide interactions with dopaminergic binding sites labeled by [3H]spiroperidol in human caudate and putamen: guanyl nucleotides enhance ascorbate-induced lipid peroxidation and cause an apparent loss of high affinity binding sites.“The effect of l‐ascorbic acid is blocked by the nonselective serotonin antagonists methiothepin, clozapine, methysergide, and pizotifen, but not mesulergine, spiperone , MDL 72222, and dl‐propranolol, nor by the catecholaminergic receptor antagonists prazosin and S(−)‐sulpiride.”
Modulation of Neurosteroid Synthesis/Accumulation by l‐Ascorbic Acid in Rat Brain Tissue: Inhibition by Selected Serotonin Antagonists“While it cannot be certain … the reduction of striatal [3H]spiperone concentrations … ascorbic acid in vivo was not a result of some nonspecific alteration in the pharmacokinetics of [3H]spiperone, the in vitro observation strongly suggests that it resulted from an alteration of binding characteristics at the receptor level.”
“Preincubation with ascorbic acid at 22 degrees C produced a profound time-dependent decline in [3H]spiperone binding to membrane receptors (prepared in Tris-ascorbate buffer).”
“Abstract: Ascorbic acid , sodium ascorbate, and isoascorbic acid (the stereo‐isomer of ascorbic acid) inhibited the stereospecific binding of [3H]spiroperidol to neostriatal membrane preparations.”
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