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“ Palmitate significantly increased intracellular accumulation of S1P , whereas in the presence of AdipoRon there was increased release of S1P from cells to extracellular medium.”
“Ceramides, hexosylceramides, and sphingosine-1-phosphate significantly heightened by palmitate correlated negatively with insulin sensitivity and positively with pro-inflammatory indices.”
“Our lipidomic analysis revealed that palmitate at low and high glucose supplementation increased (dihydro)sphingosine-1-phosphate levels in INS-1 β cells.”