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“S1P increased capillary ingrowth into subcutaneously implanted Matrigel plugs in mice, and the effect of S1P was significantly reduced in mice that received NG‐nitro‐L‐arginine methyl ester (L‐NAME), an inhibitor of NOS.”
“Furthermore, NG‐nitro‐L‐arginine methyl ester , a NO synthase inhibitor, cancelled the effect of S1P on DNA synthesis, apoptosis, and NO production in vitro as well as the protective effect of S1P on cell damage in situ.”