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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Sphingosine 1-Phosphate
drug:
Interleukin-10
Research Papers that Mention the Interaction
“In maturing DC, however, S1P inhibited the secretion of tumor necrosis factor α and interleukin (IL)‐12, whereas it enhanced secretion of IL‐10.”
Sphingosine 1‐phosphate induces Chemotaxis of immature dendritic cells and modulates cytokine‐release in mature human dendritic cells for emergence of Th2 immune responses“That IL‐10 from CD4+25+ T cells incubated with S1P mediates suppressive activity was demonstrated by prevention with neutralizing anti‐IL‐10 or anti‐IL‐10 receptor antibodies.”
“These levels of S1P also enhanced IL‐10 generation by CD4+25+ T cells by up to threefold compared with that without S1P but decreased IL‐10 from CD4+25− T cells.”
Physiological sphingosine 1‐phosphate requirement for optimal activity of mouse CD4+25+ regulatory T Cells
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