Possible Interaction: Sphingosine 1-Phosphate and Fingolimod

“ Fingolimod is a functional antagonist of the sphingosine-1-phosphate receptor 1 and thereby inhibits sphingosine-1-phosphate –dependent lymphocyte egress from secondary lymphoid tissues, resulting in a pronounced lymphopenia in the peripheral blood.”

“ Fingolimod , a structural analog of sphingosine derived from fungal metabolites, is a functional antagonist of the G-protein-coupled sphingosine 1-phosphate (S1P) receptors S1P1,3,4,5.”

“It is well established that fingolimod , a modulator of the sphingosine-1-phosphate pathway , restrains the egress of CCR7+ lymphocytes from lymphatic tissues into the blood, thus resulting in reduced lymphocyte counts in peripheral blood.”

“ Fingolimod reduces inflammatory activity in multiple sclerosis (MS) by acting as a functional antagonist of sphingosine 1-phosphate (S1P) receptors.”

“Dysregulated sphingosine-1-phosphate signaling on astrocytes following fingolimod withdrawal might represent a possible contributing mechanism to disease rebound and might account for the unusual radiological and neuropathological features observed in the present case.”

“ Fingolimod is an orally bioavailable compound that antagonizes the sphingosine 1-phosphate (SP1) receptor.”

“Through binding to SP1 sites in lymphocytes, fingolimod prevents these cells from leaving the lymph nodes.”