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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“The two concentrations of Dox resulted in the regulation of SLs, including accumulations in sphingosine, sphingosine-1-phosphate , dihydroceramide, and ceramide, as well as reduced levels of hexosylceramide.”
Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis[S]“Furthermore, sphingolipids such as sphingosine-1-phosphate and ceramide modulate DXR actions by, respectively, altering its intracellular trafficking, or by sustaining the drug's contact with DNA.”
Molecular requirements for doxorubicin-mediated death in murine oocytes“Apoptosis induced by DXR in oocytes is blocked by sphingosine-1-phosphate , an inhibitor of ceramide-promoted cell death.”
“In this study, we show that S1P caused minor increases in cell proliferation or apoptosis, in a concentration-dependent manner, yet co-administration of 10 µM S1P exhibited a significant synergistic effect with chemotherapy drugs docetaxel, doxorubicin and cyclophosphamide.”
Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells
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