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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Sphingosine 1-Phosphate and Docetaxel

Research Papers that Mention the Interaction

Co-administration of S1P enhanced the cytotoxicity of anticancer drug docetaxel against MCF7 cells.
Investigational New Drugs  •  2009  |  View Paper
In this study, we show that S1P caused minor increases in cell proliferation or apoptosis, in a concentration-dependent manner, yet co-administration of 10 µM S1P exhibited a significant synergistic effect with chemotherapy drugs docetaxel , doxorubicin and cyclophosphamide.
Recently, we reported that S1P selectively induces cell apoptosis of the breast cancer MCF7 cell line at concentrations higher than 1 µM and co-administration of 1 µM S1P significantly increased the cytotoxicity of chemotherapy drug docetaxel.
Journal of Cancer  •  2013  |  View Paper