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Last Updated: 3 years ago

Possible Interaction: Sphingosine 1-Phosphate and Celecoxib

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supplement:

Sphingosine 1-Phosphate

drug:

Celecoxib

Research Papers that Mention the Interaction

“ S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib , the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.”

Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization.

American journal of respiratory cell and molecular biology • 2016 | View Paper

“ S1P also induced PGE2 and IL‐6 secretion which were reduced by the inhibitors of COX‐2 (NS‐398 and celecoxib).”

Sphingosine‐1‐Phosphate Mediates COX‐2 Expression and PGE2/IL‐6 Secretion via c‐Src‐Dependent AP‐1 Activation

Journal of cellular physiology • 2015 | View Paper

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