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Discover Supplement-Drug Interactions

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Possible Interaction: Spermine and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

Spermine , a polyamine known to interact with PIP2 and reported to inhibit lipid scrambling in resealed ghosts, was found to inhibit also the Ca(2+)-induced scrambling in LUVs and in PIP2-loaded erythrocytes, presumably by interacting with PIP2 and preventing the formation of Ca(2+)-PIP2 complexes.
Biochemistry  •  1996  |  View Paper
Millimolar concentrations of spermine and to a lesser extent of spermidine decreased the ATPase activity in the presence of phosphatidylinositol 4,5-bisphosphate (PIP2), without affecting the stimulation by phosphatidylinositol 4-phosphate (PIP).
The Biochemical journal  •  1989  |  View Paper
The formation of phosphatidylinositol 4,5-bisphosphate (PIP2) from endogenous substrate in rat liver plasma membranes was stimulated approximately 3-fold by 1 mM spermine , with half-maximal effect at 0.2 mM polyamine.
Biochimica et biophysica acta  •  1987  |  View Paper
The large spermine effects on these liposomes compared with phosphatidate- or phosphatidylinositol-containing liposomes suggested that spermine has a strong specific interaction with phosphatidylinositol 4,5-diphosphate.
Biochemistry  •  1986  |  View Paper