“ Spermine given orally to 11-day-old rats stimulated ACTH and corticosterone secretion.”
“These data indicate that (1) the hypophysial-adrenal axis is implicated in the postnatal development of the gastrointestinal tract induced by spermine and (2) spermine affects ACTH and corticosterone secretion indirectly, probably by stimulating the release of gastrointestinal hormone(s).”