Possible Interaction: Sorbitol and Xylitol

“S. mutans and L. casei can ferment mannitol and sorbitol , but are inactive towards xylitol.”

“Addition of xylitol to the bacterial suspension caused inhibition of acid production from sorbitol by Streptococcus mutans grown on sorbitol or a mixture of sorbitol and glucose.”

“The acid production activity from sorbitol in suspensions of dental plaque after the xylitol addition was somewhat lower than the acid production from sorbitol alone (p less than 0.02).”

“Addition of small amounts of xylitol to the sorbitol cultures gave a growth below that of cultures with no extra carbon.”

“p-Nitroanisole metabolism by isolated hepatic microsomes was unaffected by the addition of xylitol and sorbitol ; however, when NADH was added to microsomes, or was generated from sorbitol, sorbitol dehydrogenase and NAD(+), a synergistic increase in p-nitroanisole metabolism occurred.”

“Addition of sorbitol and xylitol significantly minimised the thermal degradation during extraction in a 100 °C water bath, as shown in measured cyanocobalamin (~145 μg/tablet) that was higher than the control (100 μg/tablet, p < 0.05).”

“Of the various alcohols tested, xylitol was the most rapidly oxidized, with sorbitol and ribitol being reduced at 65% and 58% of the xylitol rate.”

“The combination xylitol and sorbitol is particularly interesting, since xylitol inhibits the metabolization of sorbitol by Strep mutans and sorbitol also appears to potentiate the bacteriostatic effect of xylitol.”

“However, a reduced uptake of xylitol was observed in the presence of sorbitol.”

“It may be speculated that, if xylulose-P were the major inhibitor of the glycolysis instead of xylitol-P, as previously assumed, an increased concentration of xylulose-P induced by sorbitol could explain that sorbitol enhances the inhibition potential of xylitol.”

“It was furthermore observed that the presence of sorbitol enhanced the inhibitory potential of xylitol.”