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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Intracellular accumulation of sorbitol is most likely to cause depletion of other intracellular compounds including osmolytes such as myo‐inositol and taurine.”
The role of taurine in diabetes and the development of diabetic complications“ Sorbitol can cause osmotic stress and can lower nerve myoinositol and taurine levels, with decreases in Na+/K+-ATPase, which is involved in intracellular energy homeostasis.”
“Objective: In diabetes, intracellular accumulation of sorbitol resulting from the high extracellular levels of glucose leads to depletion of intracellular compounds including taurine.”
Taurine May Prevent Diabetic Rats from Developing Cardiomyopathy also by Downregulating Angiotensin II Type2 Receptor Expression“ Taurine levels decreased by 31% (p< 0.01) and myo-inositol decreased by 37% (p<0.05) in diabetic nerve as sorbitol accumulated.”
“In agreement with this generalization we find that high sorbitol or inositol has little or no effect on PK activity, but surprisingly that taurine reduces Vmax and greatly elevates Km.”
“The apparent increase in lens osmolality attributed to sorbitol was counterbalanced by an equimolar reduction in taurine concentration.”
“The reciprocal relationship between taurine and sorbitol reduces the likelihood of an osmotic mechanism for sugar cataractogenesis; the reduced lens taurine, however, may increase the risk of lens protein oxidation and subsequent cataract formation.”
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