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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Somatostatin
supplement:
Polypeptides
Research Papers that Mention the Interaction
“In sum, our results identify PP as a pivotal modulator of somatostatin secretion.”
“Its agonism by PP decreases somatostatin secretion from human islets.”
“Mouse embryonic hippocampal (mHippo E18) cells expressed NPY4Rs and their activation by PP consistently decreased somatostatin secretion.”
Pancreatic polypeptide inhibits somatostatin secretion“ Somatostatin is a 14-amino acid hormone that inhibits secretion of many other polypeptide hormones and has an additional function as a neurotransmitter.”
“CONCLUSIONS These findings show the in vitro release of VIP and PP from the VIPoma cells and also provide evidence for the direct inhibitory effect of so atostatin an alogue on both the VIP and PP re lease from the tumor cells.”
“These results indicate that somatostatin alleviates the symptoms both of early and late dumping syndrome partly by inhibiting the vasoactive intestinal polypeptide , gastric inhibitory peptide and insulin release, which are increased in dumping syndrome and may, therefore, be implicated as to have an etiological role.”
“The amount of somatostatin released after a meal thus was of sufficient magnitude to inhibit exocrine pancreatic function and PP release.”
“Ingestion of food, followed by subsequent infusion of somatostatin , resulted in marked changes in the PP peak coeluting with standard PP , while the two larger molecular forms remained relatively unchanged.”
“ Abstract Somatostatin or growth hormone release inhibiting hormone (GH-RIH) inhibits the release of a variety of polypeptide hormones and enzymes.”
“The mechanism by which somatostatin inhibits the release of these various polypeptide hormones has not been fully eluciadated.”
The interrelationship of somatostatin and guanylate cyclase activity“The present … indicate that SRIF is more potent than PST on … inhibition of food-induced release of PP ; that SRIF and PST do not influence food-induced release of gastrin; and that PST cannot inhibit food-induced release of PYY, whereas SRIF inhibits PYY release in a potent fashion.”
“In addition, since somatostatin potently inhibits of pancreatic enzyme secretion, the effects of PP and PYY were compared with somatostatin.”
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