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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Somatostatin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Baclofen and somatostatin , agonists of Gi-coupled receptors, inhibited Ca2+ signals induced by PregS and CIM0216 in mouse dorsal root ganglion (DRG) neurons.”
Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits“However, they antagonized somatostatin stimulation of intracellular calcium and behaved as partial agonists/antagonists for ERK phosphorylation.”
“In sst2A-expressing HEK293 cells, somatostatin inhibited cAMP production, stimulated intracellular calcium accumulation, and increased ERK phosphorylation.”
“In conclusion, SRIF stimulates an increase in intracellular calcium and SRE‐luciferase expression via human sst2 receptors in CHO‐K1 cells.”
“ Somatostatin and octreotide (100 nM) promptly and reversibly counteracted glucose stimulated elevations of the concentration of cytoplasmic Ca2+ ([Ca2+]i) in mouse pancreatic beta-cells.”
“On the other hand, both forms of SOM inhibit a voltage-dependent Ca current, again via a GTP-binding protein.”
“Short term secretion of calcitonin and SRIF was stimulated by calcium in vitro (0.5-4 mM) in a dose-related manner.”
“Inhibition by somatostatin involves not only a marked increase in gastrin produced by parathyroid hormone but also suppresses hypergastrinemia induced by antral infusion of acetylcholine or calcium.”
“ Somatostatin can also inhibit or largely reverse hypergastrinemia induced by calcium or acetylcholine as well as the parathyroid hormone.”
“High Ca++ concentration in the incubation medium reversed the inhibitory effect of somatostatin on glucose-induced insulin biosynthesis as well as release.”
“Although insulin output was high in the absence of glucose, this was not due to passive leak of hormone, since both removal of calcium and addition of somatostatin and epinephrine inhibited the secretion.”
“The addition of dopamine or somatostatin to low calcium medium further decreased PRL release.”
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