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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sodium Fluoride
supplement:
Tretinoin
Research Papers that Mention the Interaction
“ Retinoic acid treatment, in a time- and concentration-dependent manner, led to a decrease in phospholipase C activity when stimulated with either GTP gamma S or NaF , both of which activate the enzyme via the G-protein.”
The differentiating agent, retinoic acid, causes an early inhibition of inositol lipid-specific phospholipase C activity in HL-60 cells.“On the other hand, RA significantly inhibited PGE2-induced cAMP accumulation in a dose-dependent manner between 0.1 … 0.1 microM. This effect of RA was dependent on the time of pretreatment up to 8 h. RA also inhibited the … induced by NaF or forskolin which … adenylate cyclase.”
Effects of retinoic acid on signalling by prostaglandin E2 in osteoblast-like cells.“ Retinoic acid , which inhibited the growth of B‐16 melanoma cells, also reduced basal and MSH‐, NaF‐ , and forskolin‐stimulated AC activity in vitro.”
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