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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sodium Fluoride
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“ Sodium fluoride (20 mM) effected rapid hydrolysis of phosphatidylinositol bisphosphate ( PIP2 ) in human neutrophils.”
Relationship of phosphatidylinositol bisphosphate hydrolysis to calcium mobilization and functional activation in fluoride-treated neutrophils.“The early breakdown of phosphatidylinositol 4,5-bisphosphate in human platelets stimulated by a threshold concentration of either collagen or thrombin was inhibited by 5 mM NaF through its inhibition of phospholipase C activity.”
“Furthermore, NaF induced a rapid decrease in 32P-labeling of phosphatidylinositol-4,5-diphosphate (PIP2) with a concomitant increase of [32P]phosphatidic acid in prelabeled cells.”
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.“Incubation of 32P-prelabeled corneal epithelium with NaF (2-50 mM) resulted in increased breakdown of PIP2 and increased synthesis of phosphatidic acid.”
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