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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sodium Fluoride
supplement:
Genistein
Research Papers that Mention the Interaction
“This latter effect was quite different from that seen in RINm5F cells where the combination of 100 microM genistein and 5 mM NaF resulted in much less apoptosis than was observed with either agent alone.”
Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells.“Exposure of RINm5F cells to low concentrations of genistein or tyrphostin A25 resulted in significant inhibition of cell death … 5 mM NaF. Higher concentrations (>25 μM) were cytotoxic in the absence of NaF but, paradoxically, the combination of genistein … NaF induced less cell death than … agent was used alone.”
Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic β‐cell line, RINm5F“In contrast, genistein attenuated the contraction of the vessel evoked by the direct G-protein activator sodium fluoride ( NaF ), suggesting the involvement of tyrosine kinases in responses associated with G-protein activation.”
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