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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Sodium Fluoride and Calcium Supplement

Research Papers that Mention the Interaction

Previous studies demonstrated that a Ca pre-treatment greatly increases salivary F from a subsequent NaF rinse.
Journal of dental research  •  2008  |  View Paper
As the bioavailability of sodium fluoride (NaF) can be impaired by concomitant absorption of calcium , both drugs have to be ingested separately.
Calcified Tissue International  •  2004  |  View Paper
Pre-incubation of CA with 25 mM NaF changed CA to a Mn(2+)-dependent form with higher PTP activity.
Journal of biochemistry  •  1999  |  View Paper
Other schedules were studied as well, such as EC NaF tablets taken 1 hour after or 3 hours before the administration of calcium supplements.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1990  |  View Paper
The results were as follows: (1) When NaF is accompanied by calcium , the fluoride peak level is lower and delayed. (
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1990  |  View Paper
It is speculated that since NaF (greater than 10 mM) can complex with extracellular Ca++, and thus reduce free Ca++ concentration required for O2- generation, a NaF-dependent increase in cAMP may restore cytosolic free Ca++ by mobilizing intracellular stores of Ca++.
The American journal of the medical sciences  •  1988  |  View Paper
Prolonged osteoblast life span was the most likely explanation for the increased mean trabecular thicknesses and trabecular bone volumes seen in patients with osteoporosis, when treated with sodium fluoride plus calcium supplements or daily injections of parathyroid peptide hPTH 1-34.
Clinical orthopaedics and related research  •  1986  |  View Paper
We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5'-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.
Life sciences  •  1985  |  View Paper
This enzymatic activity is strongly stimulated by NaF and 5'-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.
Biochimica et biophysica acta  •  1976  |  View Paper
In contrast, subsequent studies showed that administration of sodium fluoride by peritoneal lavage decreased the amount of calcium removed by this procedure(5).
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1964  |  View Paper
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