Possible Interaction: Sodium Citrate and Calcium Supplement

“It has therefore been suggested that reduction of intranasal free calcium with buffer solutions such as sodium citrate may improve olfactory function in patients with smell impairment.”

“ Sodium citrate acts as a calcium sequestrant and when applied intranasally, reduces free calcium available for feedback inhibition, which should theoretically improve olfaction.”

“Chelation of calcium using sodium citrate or EDTA results in decreased platelet adhesion or retention to glass.”

“Thus, Pope 1 reported a series of experiments on rabbits in which sodium citrate was employed to lower the concentration of calcium ions with the hope of preventing adhesion formation by interfering with the coagulation mechanism.”

“In six dogs, mean serum ionized calcium, Ca++ ], was reduced from 1.11 to 0.59 mM by infusion of sodium citrate.”

“Intrarenal artery infusion of either EDTA or sodium citrate decreased ionized calcium concentration 25 per cent in renal vein blood but had no significant effect on fractional phosphate excretion.”

“In contrast, decalcifying agents such as ethylenediaminetetraacetic acid·2Na, cyclohexanediaminetetraacetic acid.2Na, sodium citrate and sodium oxalate injected intracistennally enhanced the analgesic effects of morphine, meperidine and ohton, and antagonized the antagonistic effect of calcium on the analgesic response.”

“Added sodium citrate dissolved a portion of the calcium and all of the inorganic phosphate.”

“A formulation containing sodium alginate and calcium ions , being added to sodium citrate delays gelation process until the administered solution reaches the acidic environment of the stomach.”

“(1) Calcium greatly increased crystallization of monosodium urate in otherwise pure water, by enhancing both nucleation and growth. (”