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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sodium Chloride
supplement:
Tocophersolan
Research Papers that Mention the Interaction
“This led us to hypothesize a previously unforeseen mechanism: interaction with salt cations cause the PEG to coil around the salt ions, each ion binding to many PEG oxygens, increasing the exposure of the nonpolar ethylene groups, thus increasing the effective hydrophobicity of PEG.”
Study of interaction between PEG carrier and three relevant drug molecules: piroxicam, paclitaxel, and hematoporphyrin.“Some salting-in and 'intermediate' salts (NaSCN, NaI, NaBr, NaCl , LiCl, KCl, and RbCl) inhibited the crystallization of PEG 7500 in frozen solutions.”
“Thermal analysis of an aqueous PEG 3000 solution showed a eutectic PEG crystallization exotherm at approximately -47 degrees C and a subsequent PEG crystal melting endotherm at -14.9 degrees C. Addition of sodium chloride prevented the PEG crystallization in the freeze-concentrated solution surrounding ice crystals.”
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