Possible Interaction: Sodium Chloride and Sodium Bicarbonate

“If dietary NaCl intakes are near maximum tolerance, NaHCO3 supplementation should be accompanied by reductions in NaCl intake to maintain Na balance,”

“However, sodium retention is less when given as sodium bicarbonate and sodium chloride intake is concomitantly restricted.”

“ Sodium chloride plus sodium bicarbonate is more effective than sodium chloride alone for prophylaxis of CIN and can lead to retention of better long-term renal function.”

“Additionally the pressor effect of sodium bicarbonate is much lower than that of equivalent amounts of sodium chloride.”

“Responses of renal blood flow and renal vascular resistance to NaHCO3 were strongly predicted by those to NaCl.”

“The pressor effect of NaCl strongly predicted that of NaHCO3.”

“Those getting NaCl or NaCl plus NaHCO3 lost a mean of about 1 kg less weight than those in the placebo groups.”

“Salt-dependent microstructural changes were revealed by light microscopy, where NaHCO3 supplementation resulted in greater intracellular space at 30 and 60 g kg(-1) NaCl.”

“ Sodium bicarbonate produced a significant metabolic alkalosis and an increase in urine pH. Both sodium bicarbonate and sodium chloride produced a profound diuresis.”

“Addition of NaHCO3 to NaCl treated cells exhibited further increase in the non-photochemical quenching values.”

“The combination of NaCl and NaHCO3 resulted in lower (P < 0.05) pH of digesta in the proximal ileum whereas the pH of the digesta in the distal ileum (linear) and the average pH of ileal contents (linear and quadratic) increased (P < 0.05) with phytase supplementation.”