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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sodium Chloride
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“Analysis of ET-1 and ADMA at ST in conjunction with therapy and metabolic rate of sodium chloride baths there was a significant (P < 0.01) decrease in these parameters in comparison with those before treatment.”
“In SS but not SR subjects, NaCl loading induced increases in asymmetrical dimethylarginine on both days 2 (+38%, median) and 7 (+14%, median).”
“The results demonstrated that high salt medium significantly increased the concentration of ADMA , the expression of protein arginine methyltransferase 1 (PRMT‑1) and RhoA, and the activity of ROCK, and downregulated the expression of eNOS.”
High salt medium activates RhoA/ROCK and downregulates eNOS expression via the upregulation of ADMA.
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