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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sodium Chloride
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The systemic administration of adrenocorticotrophic hormone (ACTH) stimulates the intake of sodium chloride and water in many species.”
The effect of adrenocorticotrophic hormone on water intake in mice“In rats given 340 mM NaCl instead of tap water to drink for 12 days, plasma concentrations of ACTH decreased to 105 +/- 27 pM (mean +/- S.E.M., n = 6) compared with control animals (182 +/- 13 pM).”
“It has been shown for the first time that a single in vivo injection of 0.9% NaCl causes short-term desensitization of adenylate cyclase to the repeated action of much higher doses of ACTH in vitro, presumably due to endogenous ACTH release in response to weak stress exposure.”
“A 4-h infusion of 5% (w/v) NaCl (3.8 ml/min) resulted in significantly (P less than 0.01) greater rises in ACTH and cortisol, but not aldosterone, than were observed after CRF alone.”
“This renotrophic effect of ACTH is particularly prominent in rats drinking a NaCl solution (9 g/l).”
“Additionally, NaCl shifted the concentration-response for ACTH to the right and caused an increase in the maximal activation by the hormone.”
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