Possible Interaction: Sodium Bicarbonate and Calcium Supplement

“ Calcium added to the dough when making the rolls reduced phytate degradation during fermentation and baking.”

“The increased incidence of peptic ulcer was attributed to the consumption of calcium in combination with easily absorbable alkalis ( sodium bicarbonate).”

“Significantly higher urinary calcium (adjusted using urinary creatinine) excretion was found 2 h after consuming 350 ml of carbonated soda compared to the fasting baseline level (0.15±0.01 vs. 0.09±0.01, p = 0.001).”

“This ensures that the drugs enter the circulation and prevents precipitation or inactivation as occurs when sodium bicarbonate mixes with calcium , or when sodium bicarbonate mixes with adrenaline.”

“Less calcium adsorption was found in 72 h-- NaHCO3 treated samples, than after 1 h and 24 h respectively.”

“Treatment with isotonic sodium bicarbonate resulted in a significant improvement in acid-base balance, but both total and ionised calcium decreased significantly, the decrease in ionised calcium being proportionately greater owing partly to a significant increase in the protein binding of calcium.”

“Thus, buffering increased the myocardial AMP degradation during OCCPR by increasing the flux via the 5′‐nucleotidase reaction, and SB increased the intracellular contents of sodium and calcium to a greater extent than did TBM.”

“These data suggest that NaHCO3 feeding causes a substantial increase in 1,25(OH)2D plasma level, but interferes with calcium and phosphorus absorption in the duodenum.”

“ Urinary calcium decreased (p less than 0.01) by about 50 per cent after sodium bicarbonate supplementation and potassium bicarbonate supplementation.”

“Since sodium bicarbonate and bovine serum albumin diminish the ionic calcium concentration with a pH increase, they were substituted in the buffers by Hepes or dextran, respectively.”