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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sirolimus
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Besides, mammalian target of rapamycin signaling was inhibited upon S1P treatment.”
S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.“ATP and insulin also potentiated, while rapamycin strongly inhibited, the mitogenic effects of sphingosine 1-phosphate (S1P).”
ATP-dependent Choline Phosphate-induced Mitogenesis in Fibroblasts Involves Activation of pp70 S6 Kinase and Phosphatidylinositol 3′-Kinase through an Extracellular Site“In the present study, we tested the hypothesis that S1P induces myocyte autophagy through inhibition of the mammalian target of rapamycin (mTOR), leading to improvement of left ventricular (LV) function after MI.”
Sphingosine-1-phosphate induces myocyte autophagy after myocardial infarction through mTOR inhibition.
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