Possible Interaction: Sirolimus and Resveratrol

“ Resveratrol is sensitizing the anti-tumor effects of rapamycin and the PI3K/AKT/mTOR signaling is involved.”

“The present study investigated the anti-tumor effects of the combined use of rapamycin and resveratrol in papillary thyroid cancer.”

“In addition, combination treatment with rapamycin and resveratrol induced cell death specifically in TSC1−/− MEF cells, and not in wild‐type MEFs.”

“In this study, we asked whether combination treatment with rapamycin and resveratrol could be effective in concurrently inhibiting mTOR and PI3K signaling and inducing cell death in bladder cancer cells.”

“Furthermore, resveratrol potently inhibited inflammatory factors–mediated protein kinase B/mammalian target of rapamycin signaling in neurons.”

“Interestingly, the combination of rapamycin and resveratrol selectively promoted apoptosis of cells with mTOR pathway hyperactivation.”

“The combined use of rapamycin and resveratrol enhanced AMPK, thereby restoring downstream signaling and reducing IL1β secretion.”

“Interestingly, the combination of rapamycin and resveratrol selectively promoted apoptosis of TSC2-deficient cells.”

“Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B”

“Addition of resveratrol , which alone did not affect insulin levels, potentiated the effect of rapamycin , so that the combination decreased obesity and prevented hyperinsulinemia.”

“Given distinct mechanisms of action of rapamycin and resveratrol at clinically relevant doses, their combination warrants further investigation as a potential antiaging, antiobesity and antidiabetic modality.”

“Either treatment with FOXO1 siRNA or resveratrol , a sirt1 agonist, inhibited autophagic flux, resulting in oxidative stress, mitochondrial dysfunction (MtD) and apoptosis in QBC939 cells, which were attenuated by enhancing autophagy with rapamycin.”

“The combined use of resveratrol and rapamycin resulted in modest additive inhibitory effects on the growth of breast cancer cells, mainly through suppressing rapamycin-induced AKT activation.”

“We, therefore, reveal a novel combination whereby resveratrol potentiates the growth inhibitory effect of rapamycin , with the added benefit of preventing eventual resistance to rapamycin, likely by suppressing AKT signaling.”