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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sirolimus
supplement:
Multivitamin Preparation
Research Papers that Mention the Interaction
“In vitro, induction of autophagy in human fibroblasts with tunicamycin (a reticulum stress inducer) or rapamycin (an activator of mTOR) resulted in carbamylation of multiple proteins , including vimentin.”
Autophagy, autoantigens and autoantibodies“We found that mTORC1 inhibition with low doses of rapamycin (2, 20 nM) lowered macrophage priming of IL-1b mRNA and secretion of IL-1b caused by multiple statins.”
Statins activate the NLRP3 inflammasome and impair insulin signalling via p38 and mTOR.
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