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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sirolimus
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Importantly, we demonstrate that sirolimus markedly depletes calcium (Ca2+) content in the endoplasmic reticulum and significantly decreases glucose-stimulated mitochondrial Ca2+ uptake.”
Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells“Furthermore, CA effectively inhibited the phosphorylations of phosphatidylinositol 3 kinase(PI3K), protein kinase B (Akt), mammalian target of rapamycin (mTOR).”
Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway in mice.
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