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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Sincalide
supplement:
Polypeptides
Research Papers that Mention the Interaction
“ CCK-8 , CCK-33, and GIP (100 pmol/kg) all potentiated the meal-induced plasma responses of insulin and PP , whereas plasma levels of glucagon after the meal were not affected.”
“ CCK-8 , CCK-33, and GIP were all found to increase the basal plasma levels of insulin, somatostatin, and PP ; the increases were observed already in samples taken at 2 min after the injection.”
Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man.“It was found that CCK-8 at 5.3 nmol/kg increases plasma levels of both PP and insulin when the sample was taken at 2 min, but not at 6 or 10 min, after injection.”
Effects of cholecystokinin and glucagon-like peptide 1 on the secretion of pancreatic polypeptide in mice“Similarly, the percentage of total amylase released in response to all doses of cholecystokinin octapeptide (1–100 pM) was reduced by chronic treatment with PP.”
“ITV administration of CCK-8 (4.08 micrograms/5 min) resulted in a significant elevation of plasma insulin and PP concentrations.”
“In conclusion: (1) Postprandial SLI and PP release might in part be due to the stimulatory effect of CCK-8. (”
“ PP decreased optimal amylase release evoked by OP-CCK and OP-CCK plus secretin.”
“We conclude from this that CCK-OP and related peptides do release PP and that their effect on exocrine pancreatic secretion is closely correlated with their PP-releasing capacity.”
“reduced the PP response to the 135 pmol/kg/h dose of CCK-OP by 61%.”
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