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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sincalide
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Stimulation of gastric vagal afferents by systemic administration of cholecystokinin octapeptide (CCK) inhibits gastric motility, reduces food intake, and stimulates pituitary secretion of oxytocin and adrenocorticotropic hormone in rats.”
Cholecystokinin activates catecholaminergic neurons in the caudal medulla that innervate the paraventricular nucleus of the hypothalamus in rats“Consistent with earlier reports, the present results demonstrate that CCK-8 administration to rats elevates circulating beta-endorphin and adrenocorticotropin , but not alpha-melanocyte-stimulating hormone concentrations.”
“ CCK-8 exhibits short-term cross-tolerance with ACTH in elicitation of grooming, and central CCK-8 is co-localized with CRF and stimulates ACTH and corticosterone release in the rat.”
“Cerulein evoked ACTH release whereas human gastrin 1, CCK-4 and desulfated CCK-8 only produced minimal affects on ACTH release at concentrations of 10(-4) M. In contrast, these latter three peptides were as effective as CCK-8 in inducing the secretion of amylase from pancreatic acinar cells.”
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