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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Simvastatin
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Since then, subsequent research has shown that SJW altered the pharmacokinetics of drugs such as digoxin, tacrolimus, indinavir, warfarin, alprazolam, simvastatin , or oral contraceptives.”
Clinical relevance of St. John's wort drug interactions revisited“Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or increases the clearance) of …, chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, midazolam, nifedipine, omeprazole, oral contraceptives, quazepam, simvastatin , tacrolimus, talinolol, … warfarin.”
“Products containing St John's Wort should not be given to patients with hypercholesterolemia who are on treatment with simvastatin.”
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