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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Simvastatin
supplement:
Levocarnitine
Research Papers that Mention the Interaction
“Co-administration of l-carnitine with simvastatin was associated with a significant, albeit modest, reduction in Lp(a) compared with simvastatin monotherapy in subjects with mixed hyperlipidemia and elevated baseline Lp(a) levels.”
l-Carnitine/Simvastatin Reduces Lipoprotein (a) Levels Compared with Simvastatin Monotherapy: A Randomized Double-Blind Placebo-Controlled Study“Our findings provide support for a possible role of combined treatment with l-carnitine and simvastatin in lowering Lp(a) serum levels in patients with type 2 diabetes mellitus than with simvastatin alone.”
“Moreover, a higher and more rapid normolipidemic effect was obtained after using L-carnitina associated with simvastatin with respect to the separated substances.”
“ L-carnitine co-administration decreased the intensity of aforementioned toxicity markers produced by statins treatment.”
Mitigation of statins-induced cytotoxicity and mitochondrial dysfunction by L-carnitine in freshly-isolated rat hepatocytes“Thus, independently of Co-Q10 levels, L-carnitine prevented the toxic effects of simvastatin.”
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