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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Simvastatin
supplement:
Green Tea Extract
Research Papers that Mention the Interaction
“Animal studies suggest green tea extract and/or (-)-epigallocatechin-3-gallate significantly increase the bioavailability of diltazem, verapamil, tamoxifen simvastatin , 5-fluorouracil, and nicardipine.”
An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis).“ GTE alters the pharmacokinetics of SIM , probably by inhibiting intestinal CYP3A.”
“The maximum concentrations of SIM were higher in the GTE (3.3-fold) and TAO (9.5-fold) groups.”
Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats.
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