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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Simvastatin
supplement:
Ginkgo Biloba Whole
Research Papers that Mention the Interaction
“ GBE administration reduced mean simvastatin area under the curve (AUC)0–24, AUC0–∞ and Cmax by 39% (p = 0.000), 36%(p = 0.001) and 32% (p = 0.002), respectively, but did not cause significant differences in simvastatin acid PK or its cholesterol-lowering efficacy.”
“ GBE consumption decreased simvastatin system exposure, but did not affect simvastatin acid PK.”
“However, we cannot rule out the possibility for a pharmacodynamic interaction between GBE and simvastatin in vivo.”
Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects
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