Possible Interaction: Simvastatin and Calcium Supplement

“Most importantly, the combination of calcium supplement and Sim offered synergetic osteoblast promotion therapy of osteoporosis with advanced performance than non-targeted system or mono therapy.”

“In contrast, the prevention of cholesterol production with lovastatin and simvastatin decreases the release of intracellular calcium and also decreases receptor cell surface expression.”

“We tested the hypothesis that, compared with placebo, simvastatin would reduce the progression of coronary artery calcium ( CAC ) and abdominal aortic calcium (AAC) levels in participants asymptomatic for vascular disease.”

“As simvastatin , a commonly prescribed statin, promotes Ca2+ release from sarcoplasmic reticulum (SR) vesicles, we investigated if simvastatin directly activates skeletal (RyR1) and cardiac (RyR2) ryanodine receptors.”

“In conclusion, we indicated that simvastatin increases cytosolic free calcium concentration mainly through calcium influx from extracellular solution and then induces apoptosis by activating caspase-3 via calcium-dependent protease calpain.”

“The results suggest that simvastatin might increase intracellular calcium concentration.”

“Superfusion of cultured cells with simvastatin concentrations of 10 microM and higher caused a transient increase of the cytoplasmic calcium concentration followed by an apparent second rise and cell puncture.”

“Significantly, treatment of cultured SMC with HMG-CoA reductase inhibitors, simvastatin and mevastatin, resulted in increased calcium accumulation in cultured SMC.”

“It seems … effect of simvastatin is mediated by … the influx of Ca and Na into the adrenochromaffin cells and also by suppressing Ca release from the cytoplasmic calcium store, at least … the increased NO production due to activation of NO synthase, which is relevant to neuronal nicotinic receptor blockade.”