“Co-administration of silymarin significantly increased the plasma concentration of talinolol in healthy volunteers.”
“The area under the plasma concentration–time curve from zero to 36 h (AUC0–36) and AUC0–∞ of talinolol was increased by 36.2% ± 33.2% and 36.5% ± 37.9%, respectively, by silymarin co-administration.”
“The peak plasma concentration (Cmax) of talinolol was significantly higher after silymarin administration as compared with placebo (p = 0.007).”