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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Silymarin and Talinolol

supplement:

Silymarin

Research Papers that Mention the Interaction

Co-administration of silymarin significantly increased the plasma concentration of talinolol in healthy volunteers.
The area under the plasma concentration–time curve from zero to 36 h (AUC0–36) and AUC0–∞ of talinolol was increased by 36.2% ± 33.2% and 36.5% ± 37.9%, respectively, by silymarin co-administration.
The peak plasma concentration (Cmax) of talinolol was significantly higher after silymarin administration as compared with placebo (p = 0.007).
Xenobiotica; the fate of foreign compounds in biological systems  •  2009  |  View Paper