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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Silymarin and Sirolimus

supplement:

Silymarin

Research Papers that Mention the Interaction

In addition, our results pointed out that 100 μM and 200 μM of silymarin significantly have more inhibitory effect on T cells proliferation than FK506 and rapamycin.
Iranian journal of allergy, asthma, and immunology  •  2017  |  View Paper
By adding rapamycin (1 ng/mL) and silymarin (25, 50, 100 μg/mL) over 24 hours, silymarin inhibited the pro-apoptotic effect of rapamycin on EPCs, and reversed the inhibition of proliferation, migration and angiogenesis of EPCs by rapamycin (P<0.05).
Natural product communications  •  2015  |  View Paper
Moreover, silymarin partially prevented impairment of tubular-like structure formation in Matrigel by rapamycin.
Silymarin may protect EPCs against the antiproliferative effects of rapamycin and restore their reconstructive ability.
These findings suggest that silymarin counteracts the inhibitory effects of rapamycin in EPCs.
Journal of cardiovascular pharmacology  •  2010  |  View Paper