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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Silymarin
drug:
Risperidone
Research Papers that Mention the Interaction
“Expanding the … administered with silymarin for … risperidone , the Cmax of risperidone and 9-hydroxyrisperidone were significantly increased to 2.4-fold (p < 0.001) and 1.7-fold (…, and the AUC0-t, as well to 1.7-fold (p < 0.05) and 2.1-fold (p < 0.01), respectively.”
“The repeated exposures of ilymarin, compared to single administration of silymarin, increased oral bioavailability and affected the pharmacokinetics of r isperidone and 9-hydroxyrisperidone, by inhibiting P-gp.”
“When risperidone (6 mg/kg) was co-administered with silymarin (40 mg/kg) to rats orally, the Cmax of 9-hydroxyrisperidone was significantly increased to1.3-fold (p < 0.05), while the other pharmacokinetic parameters did not show any significant differences.”
Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats
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