Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 6 months ago

Possible Interaction: Silymarin and Pitavastatin



Research Papers that Mention the Interaction

NASH increased the total amount of pitavastatin excreted into the bile 2.7-fold compared with control animals, whereas silymarin decreased pitavastatin biliary clearance approx.
Silymarin increased pitavastatin AUC0–120 min in both control and NASH animals approx.
The combination of silymarin and NASH had the greatest effect on pitavastatin AUC0–120 min, which increased 2.9-fold compared with control vehicle-treated animals.
The Journal of Pharmacology and Experimental Therapeutics  •  2019  |  View Paper