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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Silymarin and Pitavastatin

supplement:

Silymarin

Research Papers that Mention the Interaction

NASH increased the total amount of pitavastatin excreted into the bile 2.7-fold compared with control animals, whereas silymarin decreased pitavastatin biliary clearance approx.
Silymarin increased pitavastatin AUC0–120 min in both control and NASH animals approx.
The combination of silymarin and NASH had the greatest effect on pitavastatin AUC0–120 min, which increased 2.9-fold compared with control vehicle-treated animals.
The Journal of Pharmacology and Experimental Therapeutics  •  2019  |  View Paper