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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Silymarin
drug:
Pitavastatin
Research Papers that Mention the Interaction
“NASH increased the total amount of pitavastatin excreted into the bile 2.7-fold compared with control animals, whereas silymarin decreased pitavastatin biliary clearance approx.”
“ Silymarin increased pitavastatin AUC0–120 min in both control and NASH animals approx.”
“The combination of silymarin and NASH had the greatest effect on pitavastatin AUC0–120 min, which increased 2.9-fold compared with control vehicle-treated animals.”
A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model
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