“Based on these results, we conclude that oral bioavailability of paclitaxel is significantly improved by co-administration with silymarin , an inhibitor of the P-gp efflux pump and by microemulsion formulation.”
“In particular, the mean maximum plasma concentration (C(max)) and the … area under the plasma concentration-time curve (AUC(0-)(t)) of paclitaxel in the Taxol® formulation were significantly increased 3-fold and 5-fold … with control, respectively, following oral co-administration with 10mg/kg of silymarin (p<….01).”
“Oral bioavailability of paclitaxel in a Taxol® formulation was enhanced in the combination with silymarin (10 and 20mg/kg).”
“When the paclitaxel microemulsion was co-administered with silymarin (20mg/kg) orally, it caused a maximum increase in the absolute bioavailability of paclitaxel (19%).”