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Last Updated: 2 years ago

Possible Interaction: Silymarin and Paclitaxel

supplement:

Silymarin

Research Papers that Mention the Interaction

Based on these results, we conclude that oral bioavailability of paclitaxel is significantly improved by co-administration with silymarin , an inhibitor of the P-gp efflux pump and by microemulsion formulation.
In particular, the mean maximum plasma concentration (C(max)) and the … area under the plasma concentration-time curve (AUC(0-)(t)) of paclitaxel in the Taxol® formulation were significantly increased 3-fold and 5-fold … with control, respectively, following oral co-administration with 10mg/kg of silymarin (p<….01).
Oral bioavailability of paclitaxel in a Taxol® formulation was enhanced in the combination with silymarin (10 and 20mg/kg).
When the paclitaxel microemulsion was co-administered with silymarin (20mg/kg) orally, it caused a maximum increase in the absolute bioavailability of paclitaxel (19%).
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2012  |  View Paper
Higher silymarin concentrations were additive with doxorubicin and paclitaxel in both cell lines.
Cancer Chemotherapy and Pharmacology  •  2010  |  View Paper