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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Silymarin and Oxcarbazepine



Research Papers that Mention the Interaction

These findings evidence the synergistic effect of silymarin and EPG in enhancing the degree of systemic exposure to OXC and LIC in rats, which occurred in a comparable extent to that observed with verapamil.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2017  |  View Paper
Silymarin altered the pharmacokinetics of OXC , increasing its peak plasma concentration by 50% and its extent of systemic exposure by 41%, which had also impact on brain drug concentrations.
These findings support that the co-administration of silymarin and OXC should continue to be explored as a strategy to reverse the pharmacoresistance in epilepsy.
Drug and chemical toxicology  •  2019  |  View Paper